阿奇霉素 A

常用名：阿奇霉素 A

CAS号：76801-85-9

英文名：Azathramycin

中文别名：9-去氧-9a-氮杂-同型红霉素A去甲阿奇霉素|去甲阿奇霉素|阿奇霉素杂质A

阿奇霉素A名称

中文名：阿奇霉素A
英文名：(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
中文别名：9-去氧-9a-氮杂-同型红霉素A去甲阿奇霉素|去甲阿奇霉素|阿奇霉素杂质A
英文别名：更多

阿奇霉素A生物活性

描述：Azathramycin是一种抗生素。
相关类别：信号通路>>自噬>>自噬信号通路>>抗感染>>细菌研究领域>>感染
参考文献：

[1].NoedlH,KrudsoodS,LeowattanaW,Invitroantimalarialactivityofazithromycin,artesunate,andquinineincombinationandcorrelationwithclinicaloutcome.AntimicrobAgentsChemother.2007Feb;51(2):651-6.

[2].HiwatashiY,MaedaM,FukushimaH,Azithromycinsuppressesproliferation,interleukinproductionandmitogen-activatedproteinkinasesinhumanperipheral-bloodmononuclearcellsstimulatedwithbacterialsuperantigen.JPharmPharmacol.2011Oct;63(10):1320-6.

[3].Fernandez-ObregonAC.Azithromycinforthetreatmentofacne.IntJDermatol.2000Jan;39(1):45-50.

阿奇霉素A物理化学性质

密度：1.2±0.1g/cm3
沸点：815.2±65.0°Cat760mmHg
熔点：126-136ºC
分子式：C37H70N2O12
分子量：734.958
闪点：446.8±34.3°C
精确质量：734.492859
PSA：188.87000
LogP：3.11
外观性状：白色固体
蒸汽压：0.0±0.6mmHgat25°C
折射率：1.536
储存条件：-20℃

阿奇霉素A安全信息

符号：
GHS07
信号词：Warning
危害声明：H319
警示性声明：P305+P351+P338
危险品运输编码：NONHforallmodesoftransport

阿奇霉素A文献3

更多文献：Peptide-mediatedmacrolideresistancerevealspossiblespecificinteractionsinthenascentpeptideexittunnel.

Mol.Microbiol.54(2),376-85,(2004)

Expressionofspecificshortpeptidescanrendercellsresistanttomacrolideantibiotics.Peptidesconferringresistancetostructurallydifferentmacrolidesincludingoleandomycin,azithromycin,aza…

：
：Quantitativethin-layerchromatographicmethodofanalysisofazithromycininpureandcapsuleforms.

J.Chromatogr.Sci.41(1),10-6,(2003)

Avalidatedstability-indicatingthin-layerchromatographic(TLC)methodoftheanalysisofazithromycin(AZT)inbulkandcapsuleformsisdeveloped.BothAZTpotentialimpurityanddegradationprodu…

：
：Erythromycinseries.XII.Antibacterialinvitroevaluationof10-dihydro-10-deoxo-11-azaerythromycinA:synthesisandstructure-activityrelationshipofitsacylderivatives.

J.Antibiot.40(7),1006-15,(1987)

Antibacterialinvitroevaluationof10-dihydro-10-deoxo-11-azaerythromycinA(5),thenew15-memberedsemi-syntheticmacrolideantibioticwithnitrogenasadditionalatomintheaglyconeringoferyt…

：

阿奇霉素A英文别名

：9-deokso-9a-aza-9a-homoeritromicinA
：Desmethylazithromycin
：1-oxa-6-azacyclopentadecan-15-one,13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-,(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
：9a-N-desmethylazithromycin
：(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
：DD-AzaerythromycinA
：10-Dihydro-10-deoxo-11-azaerythromycinA
：9-Deoxo-9a-aza-9a-homoErythromycinA(DesmethylAzithromycin)
：(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
：9-deoxo-9-dihydro-9a-aza-9a-homoerythromycinA
：9a-aza-9-deoxo-9a-homoerythromycinA
：9-deoxo-9a-aza-9a-homoerythromycin
：AzaerythromycinA
：UNII-4LSP9FJT5B
：1-Oxa-6-azacyclopentadecan-15-one,13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-,(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
：9-deoxo-9a-aza-9a-homoerythromycinA
：Azathramycin